Premium
Abnormal umbilical vein blood flow in trisomy 9 fetus during early pregnancy
Author(s) -
Murta C. C. V.,
Moron A. F.,
Ávila M. A. P.,
Vasques F. A. P.
Publication year - 2001
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1046/j.1469-0705.2001.abs26-14.x
Subject(s) - ductus venosus , medicine , trisomy , umbilical vein , fetus , blood flow , pregnancy , obstetrics , inferior vena cava , aneuploidy , gestation , cardiology , biochemistry , genetics , chemistry , gene , in vitro , chromosome , biology
We describe a case of reversed flow in the umbilical vein and in the ductus venosus during atrial contraction of one fetus at 12 weeks' gestation with increased nuchal translucency (9.1 mm). In addition, Doppler velocimetry detected high retrograde flow in the inferior vena cava. Cytogenetic analysis of chorionic villi revealed trisomy 9. We suggest that these findings can be an early sign of chromosomal abnormalities and cardiac defects in the first trimester. To the best of our knowledge, this is the second report of reverse umbilical venous blood flow described in the literature and the earliest case reported in pregnancy.