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Chorionic villus sampling for prenatal diagnosis in Zagreb: experience with 3250 cases
Author(s) -
Podobnik M.,
Podgajski M.,
Duic Z.,
Ciglar S.
Publication year - 2001
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1046/j.1469-0705.2001.0180s1022.x
Subject(s) - medicine , abortion , chorionic villus sampling , gestation , obstetrics , gynecology , prenatal diagnosis , chorionic villi , fetus , pregnancy , genetics , biology
Background: This study comprises data from 3250 women allocated to transcervical CVS (TC‐CVS), transabdominal CVS (TA‐CVS) and transvaginal CVS (TV‐CVS). We have assessed the efficacy of transabdominal CVS compared with transcervical CVS and transvaginal CVS, and examined factors that have been implicated in causing spontaneous abortion. Methods: Over an 11‐year period, 3250 women underwent chorionic villus sampling at 9–12 weeks of gestation, by transcervical (500 patients) transabdominal (2650 patients) and transvaginal technique (100 patients). Transvaginal color Doppler was used to investigate the uteroplacental and fetal vessels in 500 pregnancies between 11 and 12 weeks of gestation (400 TA‐CVS and 100 TC‐CVS) before and after CVS procedures. Results: Five hundred (15.4%) patients underwent TC‐CVS and spontaneous abortion after TC‐CVS occurred in five cases (1.0%). 2650 (81.5%) patients underwent TA‐CVS using a 20 gauge spinal needle and abortion after TA‐CVS occurred in 11 cases (0.4%). One hundred (3.1%) patients underwent TV‐CVS using a 20‐gage needle and abortion after TV‐CVS occurred in three cases (3.0%). The spontaneous abortion rate after CVS procedures was 0.7%. Some 121 (4.6%) cases showed chromosomal aberration. The spontaneous abortion rate was lower among cases allocated to TA‐CVS after 11 weeks of gestation. There were no significant differences in mean pulsatility indices (PI) between maternal, fetal and intraplacental circulation, before and after CVS procedures. Conclusions: Transabdominal CVS has lower fetal loss rate than transcervical and transvaginal CVS.