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Prenatal diagnosis
F92Fetal biometry from 10 to 14 weeks of gestation
Author(s) -
Chatzipapas I.,
Spathopoulos Y.,
Whitlow B.,
Lazanakis M.,
Kadir R.,
Verdin S.,
Economides D.
Publication year - 2000
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1046/j.1469-0705.2000.00015-1-91.x
Subject(s) - medicine , gestation , gestational age , obstetrics , population , biparietal diameter , fetus , gynecology , prospective cohort study , obstetrics and gynaecology , nuclear medicine , pregnancy , surgery , head circumference , genetics , environmental health , biology
Background To determine fetal biometrical reference ranges from 10 to 14 weeks' gestation. Methods A prospective cross‐sectional study in a University Department of Obstetrics and Gynaecology, London. Four hundred and seventy women from an unselected population underwent a detailed assessment of fetal anatomy at 10 + °−14 +6 weeks' of gestation (confirmed by crown‐rump length) using transabdominal sonography (TAS), and transvaginal sonography (TVS) (35.3%: 166/470) when necessary. Biparietal diameter (BPD), occipito‐frontal diameter (OFD), head circumference, humerus (HU), abdominal circumference (AC), femur (FL) and foot lengths (FL) were measured and charts for centiles derived using regression analysis and a model of best fit constructed. HC/AC, BPD/OFD, BPD/FL and BPD/FL ratios were derived for each gestational age. Differences in measurements of BPD, HL and FL using TAS and TVS were examined in 39 cases using regression and t ‐test analyses. Results Centiles (2.5th, 5th, 50th, 95th, 97.5th) were derived for each biometrical parameter. New charts and tables for each biometrical parameter are presented and compared with previously published data. As expected all parameters increased with gestational age. However the BPD/FL ratio decreased significantly at 10–13 weeks and the BPD/OFD and HC/AC ratio did not change. There was no significant difference between TAS and TVS measurements of BPD ( T = 0.18, P = 0.86, R 2 = 0.846), FL ( T = −0.03, P = 0.98, R 2 = 0.764) and HL ( T = 0.17, P = 0.87, R 2 = 0.633), therefore the results were combined. Conclusion We have constructed new reference ranges for biparietal diameter (BPD), occipito‐frontal diameter (OFD), head circumference (HC), humerus (HU), abdominal circumference (AC), femur (FL) and foot lengths (Fo) from 10 + ° to 14 +6 weeks gestation. These data may be useful in the diagnosis of skeletal dysplasias and chromosomal abnormalities in early pregnancy.