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F04Prognostic value of Dopplerometry during antirecurrent hormonal therapy in patients with hyperplastic process of the endometrium
Author(s) -
Fedorova E. V.,
Lipman A. D.,
Khokhlova I. D.,
Pobedinski N. M.
Publication year - 2000
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1046/j.1469-0705.2000.00015-1-4.x
Subject(s) - medicine , danazol , basal (medicine) , hormonal therapy , endometrium , color doppler , doppler ultrasound , urology , surgery , endometriosis , ultrasonography , breast cancer , cancer , insulin
Background The purpose of study was to find out changes of Doppler parameters in all uterine arteries during antirecurrent hormonal courses and to define their role in prediction of outcomes. Method 53 patients receiving hormonal therapy (Norcolut, Provera, Danazol) after D & C were undergone 6 months monitoring by transvaginal ultrasound with Color Flow Mapping and Doppler assessment of the main uterine, arcuate, radial and basal arteries. The mean values of resistance indices (RI) were calculated after retrospective division into groups with effective ( n = 41) and effectless ( n = 12) treatment. Investigated RI data were used for statistical creation of prognostic upper and lower cut‐off levels (for P < 0.05). Results The resistance indices were:Healthy Effective
treatment Effectless
treatment Cut‐off intervals
for P < 0.05Uterine arteries 0.88 0.86 0.83 0.83–0.87 Arcuate arteries 0.78 0.74 0.72 0.65–0.80 Radial arteries 0.71 0.73* 0.65* 0.60–0.75 Basal arteries 0.57 0.62 0.57 0.48–0.68* – p < 0.10Conclusion For predicting effectiveness of hormonal treatment after two months from its beginning Doppler measurements should be carried out in Radial Arteries and RI must exceed 0.75.