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F33Application of early sonographic markers of Down syndrome to pregnancies achieved by assisted reproduction techniques
Author(s) -
Lara C.,
Bellver J.,
Iberico G.,
Remohí J.,
Pellicer A.,
SerraSerra V.
Publication year - 2000
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1046/j.1469-0705.2000.00015-1-33.x
Subject(s) - medicine , intrauterine insemination , intracytoplasmic sperm injection , fetus , crown rump length , gestation , gynecology , obstetrics , assisted reproductive technology , in vitro fertilisation , gestational age , pregnancy , artificial insemination , insemination , andrology , first trimester , sperm , pregnancy rate , infertility , biology , genetics
Background Biochemical markers need to be adjusted in pregnancies following assisted reproduction techniques (ART) for proper interpretation of second trimester Down syndrome screening results. However, little information is available on the application of first trimester sonographic markers of Down syndrome to ART pregnancies. Methods The crown‐rump length (CRL), nuchal translucency (NT), fetal heart rate (FHR), femur length (FL) and humerus length (HL) were measured transvaginally in 301 normal fetuses (159 singletons and 142 twins) between 10 and 14 weeks gestation. A control group of naturally conceived fetuses ( n = 91) was compared to those obtained after intrauterine insemination ( n = 35), in vitro fertilization (IVF) ( n = 35), intracytoplasmic sperm injection (ICSI) ( n = 47), combined IVF‐ICSI ( n = 25) and ovum donation ( n = 68). Adjustment for gestational age was performed by dividing the sonographic measurement by the CRL in each fetus. Results Naturally conceived fetuses showed similar NT/CRL, FHR/CRL, FL/CRL and HL/CRL ratios than ART fetuses ( P = NS). No differences were observed either between the various ART pregnancies ( P = NS). Conclusion Our preliminary results suggest that no adjustments are needed for the application of early sonographic markers of Down syndrome to pregnancies achieved by ART.