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F13The influence of angiotenzin converting enzyme inhibitors on adnexal tumor vascularization
Author(s) -
Jurisic A.,
Antic N.,
Maglic R.,
Tajfl P.,
Jankovic S.
Publication year - 2000
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1046/j.1469-0705.2000.00015-1-13.x
Subject(s) - medicine , hemodynamics , analysis of variance , statistical significance , vascular resistance , color doppler , benign tumor , urology , pathology , surgery , ultrasonography
Background The aim of this study was to investigate the influence of antihypertensive therapy with angiotenzin converting enzyme inhibitors (ACE) on adnexal tumor hemodynamic parameters. Method Patients were classified into the four groups: ace benign (29), ACE malignant (17), benign (188), malignant (71). Hemodynamic studies of tumor vascularization were performed by transvaginal color/power Doppler and Pourcelot resistance indices (RI) were measured in tumor tissue. Statistical analysis was performed by analysis of variance (ANOVA). Results A total of 305 patients were examined and 1411 blood vessels were analyzed. In ACE benign group 125 resistance indices were analyzed; in ACE malignant group 136 RIs; in benign group 644 RIs and in malignant group 506 RIs were measured. Mean RI values were BACE = 0.469 ± 0.124, MACE = 0.409 ± 0.096, B = 0.564 ± 0.121 and M = 0.390 ± 0.095. Analysis of variance showed high statistical significance between the groups, where RI in ACE benign group was significantly lowered. Conclusion The analyzed data in our study indicate that antihypertensive therapy with angiotenzin converting enzyme inhibitors may significantly reduce vascular resistance indices (RI) in patients with benign adnexal tumors who received that therapy at the time of ultrasonographic examination.