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WS12‐03Uteroplacental resistances and maternal cardiac function in normal and hypertensive pregnancy: a Doppler and echocardiographic study
Author(s) -
Valensise H.,
Vasapollo B.,
Novelli G. P.,
Larciprete G.,
Arduini D.,
Galante A.,
Romanini C.
Publication year - 2000
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1046/j.1469-0705.2000.00009-1-70.x
Subject(s) - medicine , isovolumetric contraction , cardiology , diastole , gestation , pregnancy , diastolic function , vascular resistance , hemodynamics , blood pressure , biology , genetics
Objective To verify the existence of a relationship between maternal cardiac function and peripheral hemodynamic parameters in normal and gestational hypertensive women. Methods 43 normotensive primigravidae were evaluated at 12 ± 1, 21 ± 1, and 33 ± 1 weeks of gestation with uterine artery color Doppler and maternal echocardiographic examination comparing data of the third trimester with those of 21 gestational hypertensive women. Results The 43 healthy women showed a decrease in Uterine Resistance Index (RI) from I° to II° trimester (0.72 ± 0.10 vs. 0.54 ± 0.09, P < 0.001) and modifications in Diastolic function parameters: E wave velocity and E/A ratio decreased; A wave velocity and deceleration time of the E wave increased; the left ventricular isovolumetric relaxation time (IVRT) decreased significantly (88.7 ± 6.7, 75.6 ± 7.7, 71.1 ± 5.0 msec, P < 0.001) showing a correlation with left atrial dimensions and RI ( r = −0.38, r = 0.47, P < 0.001). In the third trimester the comparison between normal and hypertensive women showed a significant reduction in (TVR) total vascular resistances (1006 ± 212 vs. 1620 ± 469, P = 0.000) and IVRT (71 ± 5.0 vs. 92.0 ± 7.6 msec, P = 0.000). Regression analysis showed a linear correlation between IVRT and TVR ( r = 0.68; P < 0.01), Uterine RI and TVR were directly related ( r = 0.59, P < 0.001). Conclusions Maternal diastolic function analysis may be useful to identify women who fully adapt to pregnancy and at risk for development of gestational hypertension.