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WS03‐09Unilateral early timed vaginal ultrasound guided follicular aspiration (ETFA) 10–12 h after hCG prevents the syndrome of serious ovarian hyperstimulation
Author(s) -
Tomazevič T.,
MedenVrtovec H.,
Geršak K.,
Bokal E.
Publication year - 2000
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1046/j.1469-0705.2000.00009-1-23.x
Subject(s) - ovarian hyperstimulation syndrome , medicine , gynecology , follicular phase , infertility , ovary , controlled ovarian hyperstimulation , live birth , obstetrics , ultrasound , incidence (geometry) , pregnancy , in vitro fertilisation , radiology , genetics , physics , optics , biology
Aim To prevent the syndrome of severe ovarian hyperstimulation in IVF/ET cycles at high risk for the syndome of ovarian hyperstimulation by early timed unilateral ultrasound guided aspiration of one ovary (12 h after hCG). Method. We evaluated the preventive effect of ETFA by analysing the data on 821 cycles at high risk for SOHSS performed during the years 1987–99. In all cycles the high risk for SOHSS was defined by the estradiol values > 3000 pg/ml and more than 8 follicles > 14 mm plus intermediate and small follicles in each ovary on ultrasound. Results In the group of :729 female infertility cycles at high risk for SOHSS with preventive ETFA there were no cases of SOHSS. In the control group of 92 IVF/ET female infertility without ETFA there were 12 cases of SOHSS ( P < 0.0001). No difference in live birth rate (17% vs. 16%) was noted. The results prove the preventive effect of ETFA. It is based on early timed withdrawal of paracine substances which are present in the follicular fluid. Conclusion The vaginal ultrasound guided ETFA is another successful option to decrease the incidence of severe OHSS in assisted reproduction.