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WS03‐08Diagnosis and treatment of PCO syndrome – what is the place of ultrasound
Author(s) -
Šimunic V.
Publication year - 2000
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1046/j.1469-0705.2000.00009-1-22.x
Subject(s) - medicine , hirsutism , follicular phase , polycystic ovary , menstrual cycle , gynecology , acne , menstruation , sex hormone binding globulin , ultrasound , urology , physiology , hormone , endocrinology , androgen , diabetes mellitus , radiology , insulin resistance , dermatology
Ultrasound characterization of ovarian morphology and vascularisation has become an important part of gynaecological endocrinology. PCO syndrome is the most prevalent endocrinological problem in women during reproductive period of life. The us diagnostic accuracy has advanced from recognition of ovarian size (volume), characteristic follicular distribution and volume of dense ovarian stroma, to blood flow changes in the uterine and ovarian stromal vessels. Improvement has been made by using innovations such as 3D US, colour and pulsed Doppler US, which allows US quantitative analysis of the ovarian stroma. In the PCOS the ovarian stroma is the source of hyperandrogenemia. One hundred and thirty‐two patients with PCOS, diagnosed by us and endocrinological findings, underwent further clinical, US and endocrine evolution during various kinds of therapy (metformine, ovarian drilling, oral contraception, flutamide and finasteride treatment). Mean age of the PCO patients was 25.5 years (range 15–48), 59.3% were obese (BMI = 28), 75.6% had signs of hirsutism, 43.02% presented with acne and 88.5% have had irregular menstrual cycle. Ultrasound findings (TVUS, colour and pulsed Doppler, 3D US) and hormonal evaluation (FSH, LH Androstendion, DHEA‐a, T, Free T, SHBG, 3 α diol) were performed prior, during and at the end of the therapy. Comparison has been made between these five groups of patients.