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P117Echocardiographic findings in fetuses with trisomy 18
Author(s) -
Holan M.,
Ferianec V.,
Pohlodek K.,
Kaldararova M.,
Benedekova M.
Publication year - 2000
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1046/j.1469-0705.2000.00004-1-116.x
Subject(s) - medicine , trisomy , atrioventricular septal defect , gestation , fetus , ventricle , double outlet right ventricle , heart disease , congenital malformations , pediatrics , cardiology , pregnancy , genetics , biology
The aim of this study was to present our 4 cases of trisomy 18, with a congenital heart defect detected during the last 6 months. Results Two complex congenital heart defects (CHD) with a very similar anatomy were found during a prenatal ultrasonographic examination – Double outlet right ventricle (DORV) with complete atrioventricular septal defect (AVSDC) – in the 20th and 38th week of gestation and in other two cases – in the 19th and 21st week of gestation – an isolated muscular ventricular septal defect (VSD) was proved. In All fetuses also noncardiac (central nervous, gastro‐intestinal and uropoetical) congenital malformations were present. Conclusion Trisomy 18 (Edwards sy) occurs approximately in 1:7000 live births. 95–100% of these newborns have some form of CHD. Because of a very poor prognosis a surgical correction is usually not considered. Left to their natural course, death occurs at the age of one hour to 18 months, the median life expectance is 5–48 days, according to the presence of severe CHD and associated anomalies.