Premium
P102Preterm newborns with normal flow velocimetry and elevated S100B blood cord levels
Author(s) -
Grondona C.,
Gazzolo D.,
Lituania M.,
Vinesi P.,
Marii E.,
Di Iorio R.,
Marras M.,
Bruschettini P. L.,
Michetti F.
Publication year - 2000
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1046/j.1469-0705.2000.00004-1-101.x
Subject(s) - medicine , gestation , gestational age , fetus , asphyxia , cord blood , obstetrics , apgar score , cord , birth weight , pregnancy , surgery , biology , genetics
S100B blood cord levels were significantly higher in the pretem group (1.31 ± 0.64 vs. 0.47 ± 0.35 g/L; P < 0.001), peaking in earliest weeks of gestation, and progressively decreased near term, being undetactable or at the limit of sensitivity in the term group. A significant correlation between S100B blood cord levels and gestational age was observed in all considered fetuses ( r = −0.69; P < 0.01). We investigated 58 pregnancies (30 at term and 28 preterm), with normal flow velocimetry waveforms, whose delivery was between 27 and 42 weeks' gestation. Exclusion criteria were: multiple pregnancies, IUGR, gestational hypertension, diabetes and infections, fetal malformations, chromosomal abnormalities, perinatal asphyxia, and distocia. At birth, all newborn infants showed normal clinical conditions and no neurological injury was observed at the discharge from the Hospital. As expected, gestational age at birth (32.2 ± 3.1 vs. 39.4 ± 1.4 weeks) and birthweight (1859 ± 723 vs. 3250 ± 210 g) were higher in the term group ( P < 0.01 for both), while no significant differences were observed regarding delivery mode, Apgar score at 1st (8 ± 2 vs. 9 ± 1) and 5th min (9 ± 1 vs. 8 ± 1) and gender (preterm female/male: 13/15; term female/male: 16/14). S100B levels significantly higher in female preterm and term fetuses (preterm 1.65 ± 0.48 vs. 0.99 ± 0.61; term 1.14 ± 0.69 vs. 0.75 ± 0.51, respectively; P < 0.05 for both).