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Perinatal management of fetal hemolytic disease due to Rh incompatibility combined with fetal alloimmune thrombocytopenia due to HPA‐5b incompatibility
Author(s) -
Schild R. L.,
Hoch J.,
Plath H.,
Geißen C.,
Fahnenstich H.,
Dame C.,
Hansmann M.
Publication year - 1999
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1046/j.1469-0705.1999.14010064.x
Subject(s) - medicine , fetus , neonatal alloimmune thrombocytopenia , fetal hemoglobin , hemolytic disease of the newborn (abo) , platelet , hemolytic anemia , erythropoiesis , red cell , erythropoietin , umbilical vein , pregnancy , immunology , obstetrics , anemia , biochemistry , genetics , chemistry , in vitro , biology
We report our experience in the perinatal management of a complex case of fetal hemolytic disease primarily due to Rhesus incompatibility combined with fetal alloimmune thrombocytopenia. The lowest fetal hemoglobin and platelet levels were 2.6 g/dl and 13 000/µl, respectively. Intrauterine treatment consisted of six transfusions of packed red cells into the umbilical vein and one transfusion of platelets. The neonate required four transfusions of packed red cells to correct her hyporegenerative erythropoiesis. Postnatal management also included one platelet transfusion, intravenous immunoglobulins and erythropoietin. Although some degree of fetal thrombocytopenia may invariably be found in fetal red cell incompatibility, other rare causes need to be excluded. Copyright © 1999 International Society of Ultrasound in Obstetrics and Gynecology