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Prenatal diagnosis of trisomy 18 at the 10–14‐week ultrasound scan
Author(s) -
Sherod C.,
Sebire N. J.,
Soares W.,
Snijders R. J. M.,
Nicolaides K. H.
Publication year - 1997
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1046/j.1469-0705.1997.10060387.x
Subject(s) - trisomy , medicine , obstetrics , obstetrics and gynaecology , fetus , prenatal diagnosis , singleton , ultrasound , aneuploidy , pregnancy , gynecology , radiology , chromosome , genetics , biology , biochemistry , chemistry , gene
A beneficial consequence of screening for trisomy 21 by a combination of maternal age and fetal nuchal translucency thickness (NT) at 1O–l4 weeks is the early diagnosis of trisomy 18. In a multicenter study of 91 091 singleton pregnancies there were 106 fetuses with trisomy 18 and (83% were identified by NT screening. Trisomy 18 was also associated with early onset intrauterine growth retardation, decreased fetal heart rate and the presence of exomphalos. Copyright © 1997 International Society of Ultrasound in Obstetrics and Gynecology