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Dandy–Walker malformation diagnosed before 21 weeks of gestation: associated malformations and chromosomal abnormalities
Author(s) -
Ulm B.,
Ulm M. R.,
Deutinger J.,
Bernaschek G.
Publication year - 1997
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1046/j.1469-0705.1997.10030167.x
Subject(s) - medicine , ventriculomegaly , fetus , prenatal diagnosis , gestation , gestational age , obstetrics , dandy–walker syndrome , dandy , concomitant , pregnancy , hydrocephalus , surgery , genetics , biology , art , literature
This study examined rates of concomitant structural and chromosomal abnormalities in 14 fetuses with a diagnosis of Dandy‐Walker malformation or Dandy‐Walker variant before 21 weeks' gestational age, compared to 14 fetuses with a diagnosis of Dandy–malformation or variant between 21 weeks' gestation and delivery. A total of 24 fetuses had Dandy–malformation and four had Dandy–variant. Eight of the fetuses with the malformation had ventriculomegaly: one of the fetuses with early diagnosis and seven with later diagnosis ( p = 0.027). None of the fetuses with Dandy‐Walker variant had ventriculomegaly. The overall prevalence of concomitant structural abnormalities was 13/28; 8/l4 for fetuses with early prenatal diagnosis and 5/l4 for fetuses with late prenatal diagnosis of the malformation or the variant. Chromosomal abnormality rates were significantly higher among fetuses with early prenatal diagnosis (7/l 4) than among those with later prenatal diagnosis (l/l4; p = 0.032). Abnormal karyotypes were more prevalent among fetuses without ventriculomegaly (7/20), compared to fetuses with ventriculomegaly (l/8). We conclude that fetuses with an antenatal diagnosis of Dandy‐Walker malformation or Dandy‐Walker variant before 21 weeks' gestational age have worse prognosis than fetuses with a later prenatal diagnosis of the same defect. Copyright © 1997 International Society of Ultrasound in Obstetrics and Gynecology