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First‐trimester nuchal edema as a marker of aneuploidy
Author(s) -
Comas C.,
Martinez J. M.,
Ojuel J.,
Casals E.,
Puerto B.,
Borrell A.,
Fortuny A.
Publication year - 1995
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1046/j.1469-0705.1995.05010026.x
Subject(s) - medicine , aneuploidy , obstetrics , down syndrome , nuchal translucency , first trimester , predictive value , second trimester , fetus , population , pregnancy , false positive rate , nuchal translucency measurement , gynecology , chromosome , statistics , genetics , environmental health , psychiatry , biology , gene , biochemistry , chemistry , mathematics
Targeted ultrasonographic screening for nuchal fluid accumulation during the first trimester (9–13 weeks) seems to be a recommendable method for the detection of Down's syndrome and other chromosomal anomalies in pregnant women. It compares favorably with current methods of maternal serum screening performed during the second trimester. Using a 4‐mm cut‐off value, the detection rate of aneuploidy among our population was found to be 57.1%, with a false‐positive rate of 0.7% and a positive predictive value of 72.7%. Chromosomal analysis should be considered for fetuses with nuchal translucency equal to or greater than 4 mm in the first trimester. Copyright © 1995 International Society of Ultrasound in Obstetrics and Gynecology