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Extracardiac anomalies, aneuploidy and growth retardation in 100 consecutive fetal congenital heart defects
Author(s) -
Respondek M. L.,
Binotto C. N.,
Smith S.,
Donnenfeld A.,
Weil S. R.,
Huhta J. C.
Publication year - 1994
Publication title -
ultrasound in obstetrics and gynecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.202
H-Index - 141
eISSN - 1469-0705
pISSN - 0960-7692
DOI - 10.1046/j.1469-0705.1994.04040272.x
Subject(s) - medicine , hypoplastic left heart syndrome , heart disease , aneuploidy , growth retardation , karyotype , atrioventricular canal , fetus , atrioventricular septal defect , cardiology , down syndrome , pregnancy , pediatrics , surgery , chromosome , biochemistry , chemistry , genetics , psychiatry , biology , gene
The importance of extracardiac anomalies in 100 consecutive fetuses with congenital heart disease was evaluated. The most common cardiac diagnoses were hypoplastic left heart syndrome in 35% and atrioventricular canal defect in 15%. Extracardiac anomalies were present in 42%, abnormal karyotype in 19% and intrauterine growth retardation in 20%. There were 45 survivors (35 required neonatal surgery, ten did not require early surgery) and 80% (36/45) of the survivors had isolated congenital heart disease. Extracardiac anomalies and abnormal karyotype were more frequently present in non‐survivors ( p < 0.001). Also, intrauterine growth retardation was more frequent in non‐survivors ( p < 0.05).