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Facial premature ageing as a side‐effect following bone marrow transplantation
Author(s) -
Selvaag Edgar,
Jacobsen Niels,
Thomsen Kristian
Publication year - 2003
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1046/j.1468-3083.2003.00755.x
Subject(s) - medicine , desquamation , bone marrow transplantation , graft versus host disease , graft vs host reaction , bone marrow , erythema , autoimmunity , disease , surgery , transplantation , dermatology , pathology
Two female patients developed an acute graft versus host reaction with generalized erythema and subsequent desquamation after allogeneic bone marrow transplantation. Later, over a period of months both developed chronic graft versus host reactions with involvement of liver and lungs. Shortly after the diagnosis of the chronic graft versus host disease both patients developed severe elastosis of the facial skin. The pathogenetic linkage of the clinical picture, which resembles photodamage to graft versus host disease and autoimmunity is discussed.