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Cutaneous infection due to Scedosporium apiospermum in an immunosuppressed patient
Author(s) -
Chaveiro MA,
Vieira R,
Cardoso J,
Afonso A
Publication year - 2003
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1046/j.1468-3083.2003.00640.x
Subject(s) - scedosporium apiospermum , medicine , mycetoma , terbinafine , itraconazole , mycosis , hyaline , dermatology , voriconazole , pathology , surgery , antifungal
Scedosporium apiospermum , the anamorphic form of Pseudallescheria boydii , is a filamentous fungus with low inherent virulence. Increasing numbers of cases of this infection have been reported probably related to the rising number of immunosuppressed persons. Apart from mycetoma, cutaneous and subcutaneous infection is rarely encountered in clinical practice. We describe a case of cutaneous infection caused by Scedosporium apiospermum in a subject with rheumatoid arthritis and diabetes mellitus who was submitted to long‐term therapy with cyclosporin and corticosteroids. Histopathologic examination of a skin biopsy showed a granulomatous infiltrate with hyaline septate hyphae. Culture of two skin biopsies taken at two different observations of the woman, 3 weeks apart, allowed isolation of Scedosporium apiospermum . Therapy with itraconazole, 400 mg/day, for 3 months was effective in curing the infection.