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Skin necrosis from extravasation of Vinorelbine *
Author(s) -
Moreno de Vega MJ,
Dauden E,
Abajo P,
Bartolome B,
Fraga J,
GarciaDiez A
Publication year - 2002
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1046/j.1468-3083.2002.00564.x
Subject(s) - medicine , extravasation , necrosis , vinorelbine , vinblastine , vinca , dermis , pathology , vinca alkaloid , chemotherapy , surgery , pharmacology , vincristine , cyclophosphamide , cisplatin
Skin necrosis from intravenous infiltration of soft tissue is a rare but potentially devastating complication of intravenous therapy. Vinca alkaloids are among the intravenous drugs with the highest destructive power. We report two cases of skin necrosis from accidental extravasation of vinorelbine, a semisynthetic analogue of vinblastine, rarely described as being responsible for this event. Histopathologic study showed separation of the dermis from necrotic epidermis, associated with cytologic atypia, in both patients, and focal necrosis of eccrine glands in one of them. We consider that intravenous infusions of vinorelbine should be performed using the preventive measures and care applied for other chemotherapeutic agents with high potential for induction of skin necrosis due to extravasation.