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Successful treatment of postoperative pyoderma gangrenosum with cyclosporin
Author(s) -
Schöfer H,
Baur S
Publication year - 2002
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1046/j.1468-3083.2002.00387.x
Subject(s) - medicine , pyoderma gangrenosum , clofazimine , dapsone , isotretinoin , azathioprine , gangrene , thalidomide , dermatology , surgery , neutrophilic dermatosis , prednisolone , complication , acne , leprosy , disease , multiple myeloma
Postoperative pyoderma gangrenosum (PPG), also known as postoperative progressive gangrene of Cullen, is a rare and rapidly evolving complication of surgical procedures. Since the first description by Cullen in 1924 ( Surg Gynecol Obstet 1924; 38: 579–582) various case reports have been published. Even in typical cases PPG is often misdiagnosed and therefore wrongly treated; the unknown aetiology makes treatment difficult. The therapies used for pyoderma gangrenosum include systemic corticosteroids, azathioprine, dapsone, mercaptopurine, sulphasalazine, sulphapyridine, thalidomide, cyclophosphamide, clofazimine, isotretinoin, immunoglobulins and cyclosporin. We report on two patients with PPG following breast surgery who were successfully treated with low‐dose cyclosporin (2.5–5 mg/kg per day).