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Dermatological immune restoration syndrome: does it exist?
Author(s) -
Handa S,
Bingham JS
Publication year - 2001
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1046/j.1468-3083.2001.00337.x
Subject(s) - medicine , immunology , mucocutaneous zone , immune system , antiretroviral therapy , disease , dermatology , folliculitis , human immunodeficiency virus (hiv) , immunity , immune reconstitution inflammatory syndrome , pathology , viral load
Dermatological conditions are often an early clue to HIV infection and are common. As the disease progresses patients develop a dominant Th‐2 immunological response that may facilitate the development of a number of skin conditions. With antiretroviral therapy the Th‐1 response is restored and some skin problems regress. But, paradoxically, some cutaneous conditions may worsen, such as herpes zoster, mucocutaneous herpes, eosinophilic folliculitis and mycobacterial infections. This may be because immune restoration of a host’s immunity causes recognition of silent or latent infection and results in development of the condition.