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Phagocytized apoptotic cells in subcutaneous panniculitis‐like T‐cell lymphoma
Author(s) -
Ikeda E,
Endo M,
Uchigasaki S,
Baba S,
Suzuki H,
Kinukawa N,
Nemoto N
Publication year - 2001
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1046/j.1468-3083.2001.00230.x
Subject(s) - pathology , medicine , histiocyte , phagocytosis , cd8 , panniculitis , lymphoma , apoptosis , biology , immunology , antigen , biochemistry
We reported on a case of subcutaneous panniculitis‐like T‐cell lymphoma (SPTCL) with multiple erythematous nodular lesions on the extremities, trunk and face. Histological examination of an excised lesion revealed a dense infiltrate of markedly atypical T‐lymphoid cells expressing the CD8+ phenotype located in the subcutaneous tissue with histiocyte‐phagocytizing apoptotic cells. The ‘bean‐bag’ histiocytic cells, the characteristic finding of SPTCL, are considered to be products of haemophagocytosis. In our case the ‘bean‐bag’ cells were produced by phagocytosis of apoptotic bodies, as confirmed by electron microscopy. It is suspected that ‘bean‐bag’ cells are related not to haemophagocytosis but to phagocytosis of apoptotic cells in the CD8+ T‐cell type of SPTCL.