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Eosinophilic pustular eruption associated with transdermal fentanyl
Author(s) -
Mancuso G,
Berdondini RM,
Passarini B
Publication year - 2001
Publication title -
journal of the european academy of dermatology and venereology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.655
H-Index - 107
eISSN - 1468-3083
pISSN - 0926-9959
DOI - 10.1046/j.1468-3083.2001.00203.x
Subject(s) - medicine , fentanyl , transdermal , anesthesia , transdermal patch , dermatology , eosinophilic , pharmacology , pathology
A 70‐year‐old man developed a widespread eruption of sterile pustules on normal skin, mainly on the trunk, face and base of the limbs, 2 days after application of a fentanyl‐transdermal therapeutic system (fentanyl‐TTS) patch. The eruption was not accompanied by fever. The main histopathological finding was an intraepidermal pustule filled almost exclusively with eosinophils. Suspension of the fentanyl‐TTS led to rapid and definitive spontaneous regression of the pustules in about 10 days. A similar pustular reaction related temporally to fentanyl‐TTS administration had appeared several weeks before the current eruption.