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Yes/no reversals as neurobehavioral sequela: a disorder of language, praxis, or inhibitory control?
Author(s) -
Frattali C.,
Duffy J. R.,
Litvan I.,
Patsalides A. D.,
Grafman J.
Publication year - 2003
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1046/j.1468-1331.2003.00545.x
Subject(s) - medicine , sequela , prospective cohort study , fluency , audiology , prospective memory , neuropsychology , psychology , psychiatry , cognition , mathematics education
This study identifies a linguistic phenomenon suggestive of damage to fronto‐subcortical circuitry. Our objective was to determine the occurrence and neuroradiological/neurobehavioral correlates of yes/no reversals in corticobasal degeneration (CBD), and document occurrence of reversals in other neurological conditions. In a prospective study, we evaluated 34 CBD patients using a neuropsychologic battery and magnetic resonance imaging. Patients were subdivided into two groups: those with ( n = 11) and without ( n = 23) yes/no reversals. In a retrospective study conducted during the period of 1991–2001, we identified 33 patients for whom yes/no reversals occurred to compare correlates with prospective study findings. In the prospective study, 11 patients (32.3%) had yes/no reversals. Significant between‐group differences were found in scores of lexical fluency ( P = 0.02) and prehension ( P = 0.03). Prehension scores correlated with facial praxis ( P < 0.0001) and upper limb praxis scores ( P < 0.0001) in the yes/no reversal group only. In the retrospective study, nine CBD patients and 24 non‐CBD patients had yes/no reversals, with damage to fronto‐subcortical areas present in all patients. Results suggest an association with deficits in mental flexibility and inhibitory control. High within‐group correlations of lexical fluency and prehension with praxis scores suggest a relationship of yes/no reversals with multiple factors.