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Thrombosis complicating high dose intravenous immunoglobulin: report of three cases and review of the literature
Author(s) -
Zaidan R.,
Moallem M. Al,
Wani B. A.,
Shameena A. R.,
Tahan A. R. Al,
Daif A. K.,
Rajeh S. Al
Publication year - 2003
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1046/j.1468-1331.2003.00542.x
Subject(s) - medicine , thrombosis , complication , intravenous immunoglobulins , antibody , ischemia , intravenous immunoglobulin therapy , surgery , immunology
High dose intravenous immunoglobulin (IVG) is increasingly used in a broad range of immune mediated diseases. Thrombosis was exceptionaly reported as a complication of this therapy. We describe three cases of thrombotic complications during or soon after IVIG treatment: myocardial infarction in a man and cerebral infarctions in an elderly man, associated with peripheral ischemia in a woman. In addition we review the published cases in the literature and discuss the possible etiologic factors.