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Serum ferritin levels and early prognosis of stroke
Author(s) -
Erdemoglu A. K.,
Ozbakir S.
Publication year - 2002
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1046/j.1468-1331.2002.00472.x
Subject(s) - ferritin , medicine , serum ferritin , stroke (engine) , lesion , gastroenterology , acute stroke , prospective cohort study , surgery , mechanical engineering , tissue plasminogen activator , engineering
Iron and ferritin are known to have an important role in stroke as well as in other disorders. This prospective study was designed to determine whether administering ferritin levels might help to estimate the severity and prognosis of stroke. Fifty‐one patients with a diagnosis of acute stroke were included in the study within 24 h from onset of symptoms. Serum ferritin and cortisol levels were assayed at admission. Clinical status was determined by the Canadian Stroke Scale at admission and on day 21. Serum ferritin level was found to be higher in patients with large lesion size ( P < 0.01), deteriorated neurologic status during clinical follow‐up ( P = 0.03) and deceased patients ( P < 0.01). Serum ferritin level was correlated with neurologic deficit ( r = 0.50, P < 0.001). No correlation was found between serum cortisol and ferritin levels ( r = 0.07, P = 0.7). Serum ferritin level ( P = 0.007; OR = 1.02; 95% CI, 1.01–1.03) and large size of lesion ( P = 0.021, OR = 11.92; 95% CI; 1.46–197.12) were independently associated with mortality. Increased serum ferritin levels correlate to severity of stroke and the size of the lesion.