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Natural killer cell proliferation and circulating cytokines in patients with bilateral basal ganglia calcification
Author(s) -
Morishima T.,
Morita M.,
Kato T.,
Hoshino Y.,
Kimura H.
Publication year - 2002
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1046/j.1468-1331.2002.00449.x
Subject(s) - basal ganglia , medicine , calcification , pathology , tumor necrosis factor alpha , necrosis , basal (medicine) , natural killer cell , lymphocyte , immunology , central nervous system , biology , cytotoxic t cell , in vitro , biochemistry , insulin
Ten adult patients with symmetrical calcifications in the bilateral basal ganglia (diagnosed as physiological calcifications) were analyzed for lymphocyte subsets and cytokines. Increased number of natural killer (NK) cells were identified in the peripheral blood of seven patients by lymphocyte subset analysis. Tumor necrosis factor‐ α was detected in the sera of five patients and interferon‐ γ was detected in one patient. In summary, NK cell propagation and circulating cytokines, particularly tumor necrosis factor‐ α , may be involved in the etiology of basal ganglia calcification.