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Hypoperfusion following encephalitis: SPECT with acetazolamide
Author(s) -
Okamoto M.,
Ashida K.I.,
Imaizumi M.
Publication year - 2001
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1046/j.1468-1331.2001.00270.x
Subject(s) - acetazolamide , medicine , magnetic resonance imaging , hyperintensity , perfusion , single photon emission computed tomography , acute disseminated encephalomyelitis , encephalitis , emission computed tomography , cardiology , radiology , anesthesia , virus , virology
At 4 weeks and 8 months following initial symptoms, we performed single‐photon emission computed tomography (SPECT) with acetazolamide (ACZ) testing in a patient recovering from acute encephalitis, possibly acute disseminated encephalomyelitis (ADEM). Both regional hypoperfusion at baseline and diminished cerebrovascular reserve were seen after focal hyperintensities had disappeared in magnetic resonance imaging (MRI). The time course of SPECT abnormalities reflected the clinical course more closely than the time course of MRI abnormalities. Thus, persistent cerebral circulatory impairment probably contributed to cognitive and language deficits observed at the subacute stage.