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Central and peripheral nervous system complications following allogeneic bone marrow transplantation
Author(s) -
Solaro C.,
Murialdo A.,
Giunti D.,
Mancardi G.,
Uccelli A.
Publication year - 2001
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1046/j.1468-1331.2001.00160.x
Subject(s) - medicine , central nervous system , peripheral , peripheral nervous system , complication , bone marrow , transplantation , pathology , lymphoma , bone marrow transplantation , disease , nervous system , immunology , psychiatry
Although graft vs. host disease (GvHD) is a frequent complication of allogeneic bone marrow transplantation (BMT), involvement of the central and peripheral nervous systems (CNS and PNS, respectively) has not been demonstrated conclusively. Here, we report of a patient who, following allogeneic BMT for lymphoblastic T‐cell lymphoma, suffered a syndrome characterized by self‐remitting cerebellar and pyramidal signs associated with a progressive involvement of the peripheral nervous system (PNS). Clinical course and laboratory findings correlated with relapses of systemic GvDH, thus suggesting the possibility that involvement of CNS and PNS may be sustained by a similar pathogenic mechanism.