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Gabapentin in painful HIV‐related neuropathy: a report of 19 patients, preliminary observations
Author(s) -
La Spina I.,
Porazzi D.,
Maggiolo F.,
Bottura P.,
Suter F.
Publication year - 2001
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1046/j.1468-1331.2001.00157.x
Subject(s) - gabapentin , medicine , neuropathic pain , anesthesia , analgesic , visual analogue scale , analysis of variance , alternative medicine , pathology
The objective of this study was to assess the efficacy and safety of Gabapentin as the sole analgesic in patients with HIV‐related painful neuropathy. Nineteen patients with HIV‐related painful neuropathy were administered Gabapentin. Efficacy was evaluated with two 100‐mm Visual Analogue Scales (VAS) (0: no symptom; 100: worst symptom), rating pain and interference of pain with sleep, performed at baseline and monthly intervals. Main Pain VAS score decreased from a baseline of 55.7 ± 19.1 mm to a final 14.7 ± 18.6 mm ( anova P = 0.0001) and mean Sleep Interference VAS score decreased from a baseline of 60.4 ± 31.9 mm to a final 15.5 ± 27.7 mm ( anova P = 0.0001). Gabapentin provided significant pain relief in our patients with HIV‐associated painful sensory neuropathy.