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Delayed visual P3 in unilateral thalamic stroke
Author(s) -
Trinka E.,
Unterrainer J.,
Staffen W.,
Löscher N. W.,
Ladurner G.
Publication year - 2000
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1046/j.1468-1331.2000.t01-1-00117.x
Subject(s) - medicine , thalamus , stimulus (psychology) , infarction , cerebral infarction , audiology , anesthesia , cardiology , ischemia , psychology , myocardial infarction , radiology , psychotherapist
The P3 potential is accepted as a neurophysiological correlate of memory and attention. Delayed latencies were reported in different forms of dementias. Although the generator sites are still under debate, the thalamus may play a crucial role. The aim of this study was to investigate the influence of an unilateral thalamic ischaemic infarction on P3 generation. The event‐related P3 component of six patients (2 male, four female; mean age 47 years, range 22–63 years) with unilateral thalamic ischaemic infarction was studied and compared to age‐matched controls (five male, nine female; mean age 45.8 years; range 22–69 years). All patients underwent full clinical examination, CCT, and MRI scan. P3 potentials were recorded with a visual three stimulus discrimination paradigm. The mean P3 latency of the patient group to the target stimulus was delayed (469.7 ms, SD = 36.8) compared with the controls (378.8 ms, SD = 51.5; P < 0.05). The mean P3 latency to the unexpected stimulus was delayed in patients with thalamic infarction compared with controls [477 ms (SD = 46.6) vs. 381.2 ms (SD = 48.5); P < 0.001). Delayed P3 components of the event‐related potential (ERP) were recorded in six patients with unilateral thalamic infarction, suggesting an important role of the thalamus in the generation of the P3 potential.