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Expression of TNFα and TGFβ1 in Guillain–Barré syndrome: correlation of a low TNFα‐/TGFβ1‐mRNA ratio with good recovery and signs for immunoregulation within the cerebrospinal fluid compartment
Author(s) -
Ossege L. M.,
Sindern E.,
Voss B.,
Malin J.P.
Publication year - 2000
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1046/j.1468-1331.2000.00005.x
Subject(s) - cerebrospinal fluid , tumor necrosis factor alpha , pathogenesis , medicine , messenger rna , guillain barre syndrome , transforming growth factor , immunology , cytokine , inflammation , endocrinology , gene , biology , biochemistry
In the pathogenesis of Guillain–Barré syndrome (GBS) a dysregulation of cytokines is supposed. The protein concentration and mRNA expression of TNFα and TGFβ1 were investigated in cerebrospinal fluid (CSF) and blood in 10 patients with GBS. TNFα‐mRNA was increased at the beginning of the disease and demonstrated a decline during the time course ( P = 0.001). The level of TNFα protein was elevated in only a few patients. TGFβ1‐mRNA ( P = 0.001) and the active TGFβ1 protein ( P < 0.05) increased during the course of GBS, and the level of total TGFβ1 protein was temporarily elevated ( P = 0.005). A low ratio of TNFα‐/TGFβ‐mRNA expression correlated to a good clinical course ( P < 0.05). The results indicate an association of TNFα with disease activity. TGFβ1 seems to terminate and limit the inflammatory reactions and to promote the healing course of GBS. In addition the investigations show that in GBS immunoregulatory mechanisms also take place in the CSF compartment itself and that CSF cells are involved in the production of pro‐inflammatory as well as immunosuppressive cytokines.