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Bilateral symmetrical enhancing brainstem lesions: an unusual presentation of primary CNS lymphoma
Author(s) -
Stankoff Bruno,
Calvez Vincent,
Suarez Sandra,
Bossi Philippe,
Rosenblum Ouriel,
Conquy Leslie,
Turell Enrique,
Dubard Thierry,
Coutellier Anne,
Baril Laurence,
Bricaire François,
Lacomblez Lucette,
Lubetzki Catherine
Publication year - 1999
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1046/j.1468-1331.1999.660669.x
Subject(s) - medicine , cerebrospinal fluid , neuropsychology , dementia , cognition , pathology , frontal lobe , oncology , psychiatry , disease
Cerebrospinal fluid (CSF) and plasma HIV‐1 RNA levels were prospectively measured by the Roche Amplicor Monitor polymerase chain reaction assay in 30 HIV‐1 infected patients without central nervous system opportunistic infections. All participants completed a global neuropsychological battery consisting of Mattis Dementia Rating Scale. Additional tests were use to better characterize the type of cognitive changes with a specific reference to frontal lobe function. The neuropsychological evaluation confirmed the subcortical pattern of cognitive dysfunction. CSF and plasma HIV‐1 RNA levels were significantly correlated. No correlation was detected with either blood or CSF RNA levels and the global cognitive status, but when stratified in three cognitive subgroups, higher CSF HIV‐1 RNA levels were observed in the more cognitively impaired subjects. Our results provide further evidence that plasma and CSF HIV‐1 RNA level cannot be used as a reliable diagnostic marker for HIV‐1 associated cognitive disorders. Only longitudinal studies will determine whether a high CSF HIV‐1 level could be a risk factor for HIV‐1 dementia.