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Circadian rhythm sleep disorder associated with pontine lesion
Author(s) -
Kashihara Kenichi,
Takahashi Koji,
Shohmori Toshikiyo
Publication year - 1999
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1046/j.1468-1331.1999.610099.x
Subject(s) - medicine , circadian rhythm , sleep (system call) , lesion , rhythm , rem sleep behavior disorder , dark therapy , neuroscience , audiology , physical medicine and rehabilitation , anesthesia , electroencephalography , polysomnography , psychiatry , psychology , computer science , operating system
A 55‐year‐old man presented with excessive daytime sleepiness and a circadian rhythm sleep disorder. Magnetic resonance imaging of the brain revealed a pontine lesion distinguishable from major cerebrovascular disease, demyelination and neoplasm. Benzodiazepines, antidepressants, methylcobalamine and thyroxine failed to synchronize the circadian rhythm. Antiepileptic drugs aggravated the condition, while melatonin and protireline partially relieved the patient from poorly controlled sleep disorder. A pontine lesion appeared to be related to the circadian rhythm sleep disorder of the patient.