Premium
Worsening in seizure frequency and severity in relation to folic acid administration
Author(s) -
Guidolin L.,
Vignoli A.,
Canger R.
Publication year - 1998
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1046/j.1468-1331.1998.530301.x
Subject(s) - medicine , administration (probate law) , folic acid , epilepsy , anesthesia , psychiatry , political science , law
We report a case of increase in seizure frequency and severity in a 26‐year‐old woman receiving folic acid at a dosage of 0.8 mg/day. She had symptomatic partial epilepsy with simple and complex seizures treated with carbamazepine. She was planning pregnancy and we prescribed folic acid for prevention of neural‐tube defects. In the next few days she had a generalized tonic–clonic seizure for the first time and a significant increase in seizure frequency. Because of the temporal relation between the seizure worsening and the administration of folk acid, we hypothesize a role of folic acid in provoking seizures, as has been reported in the literature.