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PET study of striatal fluorodopa uptake and dopamine D 2 receptor binding in a patient with juvenile parkinsonism
Author(s) -
Tanji H.,
Nagasawa H.,
Araki T.,
Onodera J.,
Takase S.,
Itoh M.,
Itoyama Y.
Publication year - 1998
Publication title -
european journal of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.881
H-Index - 124
eISSN - 1468-1331
pISSN - 1351-5101
DOI - 10.1046/j.1468-1331.1998.530243.x
Subject(s) - putamen , parkinsonism , striatum , dystonia , dopamine , endocrinology , medicine , caudate nucleus , positron emission tomography , nuclear medicine , dopamine receptor d2 , chemistry , psychiatry , disease
We studied pre‐synaptic and post‐synaptic function in the striatum of a patient with juvenile parkinsonism (JP) using positron emission tomography (PET). [ 18 F]6‐fluorodopa ( 18 FDOPA), 11 C‐YM‐09151‐2 and [ 18 F]fluoro‐2‐deoxy‐ D ‐glucose ( 18 FDG) were used to measure fluorodopa uptake, dopamine D 2 receptor binding and glucose metabolism, respectively. In this patient, 18 FDOPA accumulation was decreased markedly in the caudate nucleus and the putamen bilaterally. In the images of 11 C‐YM‐09151‐2 and 18 FDG in contrast, no conspicuous changes were observed in the striatum. Thus our PET studies using 18 FDOPA, 11 C‐YM‐09151‐2 and 18 FDG provide a useful approach for assisting the diagnosis of JP, because the present findings are different from the results in patients with dopa‐responsive dystonia and hereditary progressive dystonia with marked diurnal fluctuation. Furthermore, our findings are of particular interest in relation to the pathogenesis of JP.