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Fat distribution is altered in HIV‐infected men without clinical evidence of the HIV lipodystrophy syndrome
Author(s) -
Kosmiski L,
Kuritzkes D,
Hamilton J,
Sharp T,
Lichtenstien K,
Hill J,
Eckel R
Publication year - 2003
Publication title -
hiv medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.53
H-Index - 79
eISSN - 1468-1293
pISSN - 1464-2662
DOI - 10.1046/j.1468-1293.2003.00151.x
Subject(s) - lipodystrophy , medicine , trunk , adipose tissue , body fat distribution , human immunodeficiency virus (hiv) , fat distribution , endocrinology , antiretroviral therapy , immunology , viral load , biology , ecology
Objective To determine if fat distribution is altered in HIV‐infected men without clinical evidence of lipodystrophy. Methods In a cross‐sectional design, 14 protease inhibitor (PI)‐treated men with lipodystrophy and 12 PI‐treated and five PI‐naive men without clinical evidence of lipodystrophy underwent body composition and fat distribution analysis by dual‐energy X‐ray absorptiometry and computed tomography. Their fat distribution was compared to 43 uninfected male controls matched for age and BMI. Results The percent of body fat in the trunk of men with HIV lipodystrophy was significantly greater compared to both HIV‐infected and healthy controls. The percentage of body fat in the extremities was significantly lower in men with HIV lipodystrophy compared to both HIV‐infected and healthy controls. HIV‐infected men without clinical evidence of lipodystrophy also had a significantly greater percentage of total body fat in the trunk and a significantly lower percent of body fat in the extremities compared to healthy controls. Among the HIV‐infected men, age was an independent predictor of truncal and extremity adiposity. Conclusion This study suggests that a continuum of change is present in the adipose organ of HIV‐infected men on antiretroviral therapy. Physical examination alone can miss significant changes in body fat distribution in HIV‐infected patients.