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The mechanism of effect of growth hormone on preadipocyte and adipocyte function
Author(s) -
Nam S. Y.,
Lobie P. E.
Publication year - 2000
Publication title -
obesity reviews
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.845
H-Index - 162
eISSN - 1467-789X
pISSN - 1467-7881
DOI - 10.1046/j.1467-789x.2000.00015.x
Subject(s) - adipocyte , endocrinology , adipogenesis , medicine , anabolism , adipose tissue , mechanism (biology) , mechanism of action , lipoprotein lipase , triglyceride , adipose triglyceride lipase , hormone , hormone sensitive lipase , function (biology) , growth hormone , biology , lipolysis , chemistry , cholesterol , microbiology and biotechnology , biochemistry , in vitro , philosophy , epistemology
Summary Growth hormone (GH) is not only the major regulator of postnatal somatic growth but also exerts profound effects on body composition through a combination of anabolic, lipolytic and antinatriuretic actions. GH enhancement of the lipolytic activity of adipose tissue in combination with a reduction of triglyceride accumulation via inhibition of lipoprotein lipase activity appears to be the major mechanism by which GH results in a reduction of the total fat mass. Recently, much progress has been made in understanding the molecular mechanism by which GH affects cellular function. This review provides a brief discourse and summary of the mechanism of effects of GH on preadipocyte/adipocyte function. It is intended to provide a functional understanding of the mechanism of action of GH as it relates to adipogenesis and adipocyte function.