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Can animal models predict food allergenicity?
Author(s) -
Kimber Ian,
Dearman Rebecca J.
Publication year - 2001
Publication title -
nutrition bulletin
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 40
eISSN - 1467-3010
pISSN - 1471-9827
DOI - 10.1046/j.1467-3010.2001.00125.x
Subject(s) - food allergy , microbiology and biotechnology , food safety , novel food , risk analysis (engineering) , food allergens , genetically engineered , medicine , biology , allergy , immunology , pathology , biochemistry , gene
Summary The development of genetically modified crops requires that appropriate safety assessment procedures are in place. One important consideration is food allergy, the need being to determine whether, and to what extent, the products of novel genes introduced into crop plants have the potential to cause allergic sensitisation. Although there are available approaches to allergenicity testing, there is a need for appropriate animal models that are able to supplement and support existing methods and provide a more direct assessment of the allergenic potential of novel proteins. Although doubts have been expressed regarding the feasibility of developing animal models suitable for this purpose, progress has been made. The purpose of this article is to review recent developments and to consider the potential value of animal models in food allergy safety assessment.