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Dietary sphingomyelin and other sphingolipids in health and disease
Author(s) -
Schmelz Eva M.
Publication year - 2000
Publication title -
nutrition bulletin
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.933
H-Index - 40
eISSN - 1467-3010
pISSN - 1471-9827
DOI - 10.1046/j.1467-3010.2000.00031.x
Subject(s) - sphingolipid , sphingomyelin , ceramide , sphingosine , colorectal cancer , disease , carcinogenesis , biochemistry , biology , lipid signaling , microbiology and biotechnology , chemistry , cancer , medicine , cholesterol , enzyme , receptor , apoptosis
Summary Sphingolipids are found in all eukaryotic and some prokaryotic cells and therefore most foods contain varying amounts. They are digested in the intestinal tract, and the bioactive metabolites (i.e. ceramide, sphingosine) are released. In mouse models, the supplementation of the diet with complex sphingolipids significantly reduced early stages in colon carcinogenesis and tumour formation, providing an insight into the association between diet and cancer.