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Formulation and development of a patch containing tamarind fruit extract by using the blended chitosan–starch as a rate‐controlling matrix
Author(s) -
Viyoch J.,
Patcharaworakulchai P.,
Songmek R.,
Pimsan V.,
WittayaAreekul S.
Publication year - 2003
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1046/j.1467-2494.2003.00177.x
Subject(s) - chitosan , starch , permeation , chemistry , corn starch , swelling , sorption , food science , materials science , horticulture , membrane , composite material , organic chemistry , biology , biochemistry , adsorption
Synopsis A cosmetic patch containing tamarind fruit extract was formulated and developed by blending two types of natural polymers: chitosan with molecular weight of 100 000 and starch such as corn, potato or tapioca starch. The physicochemical characteristics, i.e. flexibility, colour, transparency, integrity, gloss, water sorption and bioadhesion property and the stability of the patch without tamarind content were investigated. Stability test was performed by keeping the prepared patches at 4 °C, at room temperature or at 45 °C for 2 weeks. The results showed that the formulations composed of chitosan:corn starch ratio of 4.5 : 0.5 (CC 4.5 : 0.5 ) and chitosan:tapioca starch ratios of 4.5 : 0.5 (CT 4.5 : 0.5 ) and 4.0 : 1.0 (CT 4 : 1 ) provide patches with favourable physical characteristics, high water sorption, good bioadhesion ability and good stability. After the lyophilized tamarind extract in an amount corresponding to 5% of tartaric acid was incorporated into the formulations of CC 4.5 : 0.5 , CT 4.5 : 0.5 and CT 4 : 1 , the ability of the patches to adhere to skin was improved. However, after keeping the test patches at room temperature or at 45 °C for 6 weeks, their colours were intensified while their flexibilities and skin adhesion properties decreased. A 12‐h in vitro permeation was investigated by studying the cumulative amount of tartaric acid permeated through the Silastic ® membrane (Dow‐Coming, Midland, MI, USA). The CC 4.5 : 0.5 patch tended to give the highest amount of tartaric acid released. The release pattern of all the blended polymeric matrices was exhibited in two distinct phases: the rapid phase, where the flux averaged 3.61 µg min −1 mm −2 ; and the slow phase, where the flux averaged 1.89 µg min −1 mm −2 .