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A Comparison of Biological Activities of a New Soya Biopeptide Studied in an In Vitro Skin Equivalent Model and Human Volunteers
Author(s) -
AndreFrei V.,
Perrier E.,
Augustin C.,
Damour O.,
Bordat P.,
Schumann K.,
Förster TH.,
WaldmannLaue M.
Publication year - 1999
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1046/j.1467-2494.1999.211929.x
Subject(s) - in vivo , in vitro , skin equivalent , glycosaminoglycan , human skin , fibroblast , dermis , epidermis (zoology) , dermal fibroblast , chemistry , pharmacology , matrix (chemical analysis) , biochemistry , biology , keratinocyte , anatomy , microbiology and biotechnology , chromatography , genetics
During aging, the epidermis and dermis become thin and an efficient anti‐aging product should be able to stimulate the metabolism of senescent fibroblast and keratinocytes, in order to increase the quantity of extra‐cellular matrix components such as collagen and glycosaminoglycans. A study performed in parallel on an in vitro skin equivalent model, and in vivo, with human volunteers, demonstrated the efficacy of one specific soya biopeptide for anti‐aging properties. Such a biopeptide induces a significant increase of glycosaminoglycans synthesis in vitro and in vivo after a one‐month treatment. We also showed that this new cosmetic ingredient is able to stimulate favourably the collagen synthesis in vitro and in vivo. This study provided the proof for anti‐aging properties of a new soya biopeptide and also validated the skin equivalent model developed for this experimentation as an alternative method to animal or human testing for some cosmetic efficacy evaluations.