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The Effects of Areca Catechu L Extract on Anti‐Inflammation and Anti‐Melanogenesis
Author(s) -
Lee KunKook,
Choi JungDo
Publication year - 1999
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1046/j.1467-2494.1999.196590.x
Subject(s) - chemistry , butylated hydroxytoluene , pharmacology , catechu , antioxidant , traditional medicine , areca , lipid peroxidation , anti inflammatory , hyaluronidase , ascorbic acid , biochemistry , food science , medicine , enzyme , structural engineering , nut , engineering
Ethanolic extract (CC‐516) from Areca catechu L was prepared and its various biological activities were evaluated, CC‐516 showed potent anti‐oxidative, free radical scavenging, and anti‐hyaluronidase activity. Anti‐oxidative effect of CC‐516 (IC : 45.4 μg/ml) was lower than butylated hydroxytoluene (IC: 5μg ml), but similar to tocopherol and higher than ascorbic acid. Especially, CC‐516 exhibited relatively high free radical scavenging activity (IC: 10.2 μg/ml) compared to control. CC‐516 inhibited effectively hyaluronidase activity (IC: 416 μg/ml), showed inhibition in vivo on delayed hypersensitivity as well as croton‐oil induced ear edema in mice when it was topically applied. These results strongly suggest that CC‐516 may reduce immunoregulatory/inflammatory skin trouble. Also, from the results, we have elucidated that CC‐516 showed anti‐allergic and anti‐cytotoxicity activity. The whitening effect of CC‐516 shown by the inhibition of mushroom tyrosinase activity with IC of 0.48 mg/ml and of melanin synthesis in B16 melanoma cells. This study indicates that CC‐516 is effective on anti‐inflammatory/anti‐melanogenesis, and can be used as a new agent for cosmetics.