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In vitro skin permeation evaluation: the only realistic option
Author(s) -
Walters K.A.,
Watkinson A.C.,
Brain K.R.
Publication year - 1998
Publication title -
international journal of cosmetic science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.532
H-Index - 62
eISSN - 1468-2494
pISSN - 0142-5463
DOI - 10.1046/j.1467-2494.1998.181622.x
Subject(s) - permeation , human skin , nonylphenol , chemistry , cosmetic industry , penetration (warfare) , chromatography , cosmetics , biochemical engineering , organic chemistry , environmental chemistry , biology , biochemistry , genetics , operations research , membrane , engineering
Increasing requirements for cruelty‐free risk assessment in the cosmetic industry have led to the development of several alternative experimental evaluation strategies. Quantification of the potential dermal absorption of ingredients of cosmetic and other formulations by determination of human skin permeation rates in vitro is particularly relevant. Using modifications of standard in vitro protocols the human skin permeation rates of several cosmetic ingredients and potential contaminants have been determined under conditions designed to mimic consumer use. Skin penetration and permeation of octyl salicylate (a sunscreen), nonylphenol ethoxylates (surfactants) and three nitrosamines (potential contaminants) is discussed. The data demonstrate the usefulness of this technique as a tool in the overall risk assessment of cosmetic formulations.