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Angiotensin‐I‐converting enzyme insertion/deletion polymorphism and high urinary albumin concentration in French Type 2 diabetes patients
Author(s) -
Hadjadj S.,
Gallois Y.,
AlhencGelas F.,
Chatellier G.,
Marre M.
Publication year - 2003
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1046/j.1464-5491.2003.01024.x
Subject(s) - medicine , diabetic nephropathy , diabetes mellitus , type 2 diabetes , nephropathy , endocrinology , creatinine , angiotensin converting enzyme , genotype , albumin , polymorphism (computer science) , urinary system , gastroenterology , genetics , gene , biology , blood pressure
Aims Family‐based studies suggest a genetic basis for nephropathy in Type 2 diabetes. The angiotensin‐I‐converting enzyme (ACE) gene is a candidate gene for Type 1 diabetes nephropathy. We assessed the association between high urinary albumin concentration and ACE insertion/deletion ( I/D ) polymorphism, in French Type 2 diabetes patients. Methods We studied 3139 micro/macroalbuminuric French patients recruited in the DIABHYCAR Study, an ACE inhibition trial in Type 2 diabetes patients with renal and cardiovascular outcomes. The main inclusion criteria were age ≥ 50 years, urinary albumin concentration ≥ 20 mg/l assessed centrally during two consecutive screening visits, and plasma creatinine concentration ≤ 150 µmol/l. These patients were compared with 605 normoalbuminuric (NA; urinary albumin concentration < 10 mg/l at first screening for the DIABHYCAR Study) French patients. ACE I/D genotype was determined by nested polymerase chain reaction. Results The ACE I/D polymorphism was in Hardy–Weinberg equilibrium. The distribution of genotypes did not differ significantly between micro/macroalbuminuric and NA patients: 552 and 115 II , 1468 and 282 ID , 1119 and 208 DD ( P = 0.67). However, the ACE D allele was more frequent among normotensive micro/macroalbuminuric patients than among NA patients ( P = 0.039). Conclusions The ACE I/D polymorphism was not associated with high urinary albumin concentration in French Type 2 diabetes patients.