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Associations between insulin resistance and thrombotic risk factors in high‐risk South Asian subjects
Author(s) -
Kain K.,
Catto A. J.,
Grant P. J.
Publication year - 2003
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1046/j.1464-5491.2003.00958.x
Subject(s) - medicine , insulin resistance , plasminogen activator , fibrinogen , diabetes mellitus , von willebrand factor , plasminogen activator inhibitor 1 , endocrinology , population , fibrinolysis , risk factor , tissue plasminogen activator , insulin , gastroenterology , platelet , environmental health
Aims There is recognized association of thrombotic factors to insulin resistance in White Europeans. South Asians are more insulin resistant compared with white Europeans and express increased metabolic features of insulin resistance. The aim of the study was to determine whether there was any relationship between insulin resistance and thrombotic risk factors in healthy South Asian subjects. Methods Healthy South Asians ( n = 185) clinically free from ischaemic heart disease, ischaemic stroke or peripheral vascular disease were randomly recruited. Partial correlations of homeostasis model assessment (HOMA) (surrogate of insulin resistance) were analysed with two fibrinolytic and five coagulation factors. Results Age and gender‐adjusted HOMA was significantly correlated to plasminogen activator inhibitor‐1 (0.51, P = 0.0001), tissue plasminogen activator antigen ( r = 0.40, P = 0.0001), fibrinogen ( r = 0.28, P = 0.0001), von Willebrand factor ( r = 0.17, P = 0.03), factor XIIa ( r = 0.22, P = 0.006) factor VII antigen ( r = 0.19, P = 0.02) and factor XIII B subunit ( r = 0.30, P = 0.001). Conclusions Insulin resistance significantly clusters with fibrinolytic and coagulation factors in South Asians, which may contribute to high prevalence of vascular disease in this population.