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Proposed diagnostic thresholds for gestational diabetes mellitus according to a 75‐g oral glucose tolerance test. Maternal and perinatal outcomes in 3260 Danish women
Author(s) -
Jensen D. M.,
Damm P.,
Sørensen B.,
MølstedPedersen L.,
Westergaard J. G.,
Korsholm L.,
Ovesen P.,
BeckNielsen H.
Publication year - 2003
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1046/j.1464-5491.2003.00857.x
Subject(s) - medicine , gestational diabetes , diabetes mellitus , obstetrics , pregnancy , glucose tolerance test , gestation , gestational age , endocrinology , insulin resistance , genetics , biology
Aims To study if established diagnostic threshold values for gestational diabetes based on a 75‐g, 2‐h oral glucose tolerance test can be supported by maternal and perinatal outcomes. Methods Historical cohort study of 3260 pregnant women examined for gestational diabetes on the basis of risk indicators. Information on oral glucose tolerance test results and clinical outcomes were collected from medical records. Results There was an increased risk of delivering a macrosomic infant in women with 2‐h capillary blood glucose of 7.8–8.9 mmol/l compared with women with 2‐h glucose < 7.8 mmol/l. Despite treatment, 2‐h glucose of 9.0–11.0 mmol/l and ≥ 11.1 mmol/l were both associated with increased rates of macrosomia, spontaneous preterm delivery, hypertensive complications, and neonatal hypoglycaemia. Adverse outcomes tended to be more frequent in women with 2‐h glucose ≥ 11.1 mmol/l than in women with 2‐h glucose of 9.0–11.0 mmol/l. Conclusions The risk for several maternal and perinatal complications increased with the diagnostic threshold for 2‐h glucose. Large‐scale blinded studies are needed to clarify the question of a clinically meaningful diagnosis of gestational diabetes mellitus. Until these results are available, a 2‐h threshold level of 9.0 mmol/l after a 75‐g oral glucose tolerance test seems acceptable.