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A family history of Type 2 diabetes is associated with increased plasma levels of C‐reactive protein in non‐smoking healthy adult women
Author(s) -
Pannacciulli N.,
De Pergola G.,
Giorgino F.,
Giorgino R.
Publication year - 2002
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1046/j.1464-5491.2002.00770.x
Subject(s) - medicine , insulin resistance , endocrinology , type 2 diabetes , family history , diabetes mellitus , body mass index , waist , c reactive protein , population , homeostatic model assessment , inflammation , environmental health
Aims The aim of our study was to test whether a family history of Type 2 diabetes (FH) in women is associated with plasma C‐reactive protein (CRP). Methods CRP plasma levels were measured in 162 women, aged 18–60 years; 95 had a positive family history of Type 2 diabetes in a parent or grandparent (FH + ), and 67 gave no family history of this disease (FH − ). Other measurements included: central fat accumulation, as evaluated by waist circumference; insulin resistance, as calculated by homeostatic model assessment (HOMA IR ); systolic and diastolic blood pressure; and fasting concentrations of glucose, insulin, and lipids. Results CRP plasma levels were significantly higher in FH + than in FH − subjects. Moreover, CRP was independently associated with age, body mass index, waist circumference, HOMA IR , and FH. Conclusions Our study, performed in a selected population of women free from well‐known risk factors for atherothrombosis, demonstrates that subjects with a family history of Type 2 diabetes have higher CRP plasma levels than age‐ and BMI‐matched controls with no family history. Our results show that a family history of Type 2 diabetes is an independent contributor of CRP concentrations, in addition to age, total fatness, central fat accumulation, and insulin resistance. Diabet. Med. 19, 689–692 (2002)