Premium
A comparison of the Neuropen against standard quantitative sensory‐threshold measures for assessing peripheral nerve function
Author(s) -
A. N. Paisley,
C. A. Abbott,
C. H. M. Van Schie,
A. J. M. Boulton
Publication year - 2002
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1046/j.1464-5491.2002.00706.x
Subject(s) - medicine , sensation , peripheral neuropathy , sensory threshold , peripheral , quantitative sensory testing , diabetes mellitus , neuropathic pain , ankle , diabetic neuropathy , anesthesia , sensory system , physical medicine and rehabilitation , surgery , psychology , neuroscience , cognitive psychology , biology , endocrinology , cognitive science
Aims To investigate the efficacy of the Neuropen, a new clinical device that assesses both pain and pressure perception, to evaluate peripheral nerve function in diabetic patients compared with standard clinical testing methods. Methods Peripheral nerve function was assessed in 124 diabetic patients attending a multidisciplinary diabetes clinic, using (i) the modified Neuropathy Disability Score (NDS), derived from assessment of vibration, pinprick (pain), temperature sensation plus ankle reflexes, and (ii) vibration perception threshold (VPT) measured at the hallux. Patients were stratified into various neuropathic groups according to their NDS score. In addition, nerve function was assessed using the Neuropen, a device combining a 10‐g monofilament and a weighted Neurotip TM . Inability to feel sensation on either or both feet for each test of the Neuropen (i.e. the monofilament or the Neurotip TM ) was defined as an abnormal response. Results The sensitivity of the Neuropen to detect neuropathy compared with the NDS (score ≥ 6/10) was high using either an abnormal monofilament response (87.8%), an abnormal Neurotip TM response (91.8%) or a combination of the two (82.0%). Neuropen specificity improved, however, when the combination of abnormal monofilament and abnormal Neurotip TM responses was used (68%), rather than the individual tests (57% and 41%, respectively). Conclusions The Neuropen is a sensitive device for assessing nerve function and may provide an inexpensive alternative screening method to identify patients with moderate to severe neuropathy. Diabet. Med. 19, 400–405 (2002)