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Lighting up insulin action
Author(s) -
Tavaré J. M.,
Fletcher L. M.,
Oatey P. B.,
Tyas L.,
Wakefield J. G.,
Welsh G. I.
Publication year - 2001
Publication title -
diabetic medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.474
H-Index - 145
eISSN - 1464-5491
pISSN - 0742-3071
DOI - 10.1046/j.1464-5491.2001.00540.x
Subject(s) - medicine , insulin , action (physics) , glut4 , the internet , neuroscience , glucose transporter , bioinformatics , endocrinology , biology , computer science , world wide web , physics , quantum mechanics
Summary Understanding the mechanism of insulin action remains one of the most important challenges in modern medical biology. Recent advances in cell imaging techniques, increased processing power of computers and the internet, and the introduction of novel fluorescent reagents such as green fluorescent proteins (GFPs) have revolutionized our ability to scrutinize insulin action by time‐lapse microscopy at the single‐cell level. This article outlines some of the advances made in the authors' laboratory, with particular reference to imaging the movements of the insulin‐sensitive glucose transporter, GLUT4, and the generation of phosphoinositide lipids.